MersV1, France, Analysis, bibRecord, 000409

Molecular cloning and expression of the human interferon-γ receptor

Identifieur interne : 000409 ( France/Analysis ); précédent : 000408; suivant : 000410

Molecular cloning and expression of the human interferon-γ receptor

Auteurs : Michel Aguet [Suisse] ; Zlatko Dembi [Suisse] ; Gilles Merlin [France]

Source :

Cell [ 0092-8674 ] ; 1988.

RBID : ISTEX:308DC0861908155D74FD3E373C66626F0730C878

English descriptors

Teeft :
- Additional elements, Aguet, Amino, Amino acid sequence, Amino acids, Antibody fraction, Antigen expression, Antireceptor, Binding sites, Biological effects, Biological response, Cdna, Cdna encoding, Cdna probes, Cdna sequence, Chromosome, Clone, Cosmid, Cosmid clone, Cosmid clones, Ecorl, Ecorl fragment, Entire gene, Functional properties, Fusion proteins, High affinity receptors, Human cells, Human chromosome, Human ifnr, Human ifnr receptor, Human raji cells, Human receptor, Human receptor cdna, Human receptor gene, Hybrid, Hybrid cosmid clone, Ifnr, Immunoreactive clone, Interferon, Interferon receptors, Ligand, Ligand binding, Merlin, Monoclonal, Monoclonal antireceptor antibodies, Mouse cells, Mrna, Natural receptor protein, Nitrocellulose, Nitrocellulose membranes, Nonspecific binding, Other elements, Polyclonal antiserum, Putative signal peptide, Raji, Raji cells, Receptor, Receptor protein, Restriction enzyme maps, Same conditions, Sequential affinity chromatography, Signal peptide, Signal transduction, Somatic cell hybrids, Southern blot analysis, Specific binding, Standard protocols, Standard techniques, Transfected, Transfected mouse, Transmembrane, Transmembrane regions, Unpublished data.

Abstract

Abstract: A cDNA encoding the human interferon-γ receptor was isolated from a λgt11 expression library using a polyclonal antireceptor antiserum. The gene for this receptor was identified in a cosmid library and transfected into mouse cells. The human interferon-γ receptor expressed in mouse cells displayed the same binding properties as in human cells. However, transfected cells were not sensitive to human IFN-γ, suggesting the need for species-specific cofactors in receptor function. As inferred from the cDNA sequence, the human interferon-γ receptor shows no similarities to known proteins and represents a novel transmembrane receptor. It is most likely the product of a single mRNA and a gene located on chromosome 6q.

Url:

https://api.istex.fr/ark:/67375/6H6-V21CGZ6S-N/fulltext.pdf

DOI: 10.1016/0092-8674(88)90050-5

Affiliations:

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ISTEX:308DC0861908155D74FD3E373C66626F0730C878

Le document en format XML

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<term>Fusion proteins</term>
<term>High affinity receptors</term>
<term>Human cells</term>
<term>Human chromosome</term>
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<term>Human ifnr receptor</term>
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<term>Signal transduction</term>
<term>Somatic cell hybrids</term>
<term>Southern blot analysis</term>
<term>Specific binding</term>
<term>Standard protocols</term>
<term>Standard techniques</term>
<term>Transfected</term>
<term>Transfected mouse</term>
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<term>Transmembrane regions</term>
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<front><div type="abstract" xml:lang="en">Abstract: A cDNA encoding the human interferon-γ receptor was isolated from a λgt11 expression library using a polyclonal antireceptor antiserum. The gene for this receptor was identified in a cosmid library and transfected into mouse cells. The human interferon-γ receptor expressed in mouse cells displayed the same binding properties as in human cells. However, transfected cells were not sensitive to human IFN-γ, suggesting the need for species-specific cofactors in receptor function. As inferred from the cDNA sequence, the human interferon-γ receptor shows no similarities to known proteins and represents a novel transmembrane receptor. It is most likely the product of a single mRNA and a gene located on chromosome 6q.</div>
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Molecular cloning and expression of the human interferon-γ receptor

Molecular cloning and expression of the human interferon-γ receptor

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

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